Investigation of novel therapeutic approaches by utilizing experimental models of common conditions encountered at advanced ages such as Alzheimer’s disease, Parkinson’s disease and stroke, as well as common causes of mortality and morbidity at newborn period including hypoxic-ischemic encephalopathy and hyperoxic brain injury.
Role of Pyrimidines in Brain Functions
Investigation of effects of exogenous pyrimidines on pyrimidine synthesis and release in the brain, and role of altered pyrimidine metabolism on brain functions and neuroprotection. In this regard, our lab is the first to demonstrate the existence of pyrimidinergic neurotransmission in the rat brain in vivo (Cansev et al., Neuropharmacology 2015 Apr;91:77-86. doi: 10.1016/j.neuropharm.2014.12.019.)
Brain Phosholipid Metabolism
Investigation of the modulation of brain phospholipid synthesis by circulating precursors, outcomes of enhancing brain phospholipid levels and therapeutic potential of such modulations in management of diseases characterized with diminished phospholipid synthesis, such as Alzheimer’s.
Investigation of agents affecting the synthesis, storage and release of acetylcholine in the brain as well as modulation and outcomes of cholinergic muscarinic and nicotinic receptors.
Modulation of Cardiovascular and Neuroendocrine Systems
Investigation of compounds affecting cardiovascular parameters as well as synthesis and release of various hormones under physiologic and pharmacologic conditions.