Original Articles
1) Savci V, Goktalay G, Cansev M, Cavun S, Yilmaz MS, Ulus IH (2003)
Intravenously injected CDP-choline increases blood pressure and reverses hypotension in hemorrhagic shock: effect is mediated by central cholinergic activation. Eur. J. Pharmacol., 468: 129-139.
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2) Cansev M, Watkins CJ, van der Beek EM, Wurtman RJ (2005)
Oral uridine-5’-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res., 1058: 101-108.
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3) Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, Marzloff G (2006)
Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res., 1088: 83-92.
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4) Ulus IH, Watkins CJ, Cansev M, Wurtman RJ (2006)
Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release. Cell. Mol. Neurobiol., 26: 563-577.
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5) Cansev M, Wurtman RJ (2007)
Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils. Neuroscience, 148: 421-431.
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6) Ilcol YO, Cansev M, Yilmaz MS, Hamurtekin E, Ulus IH (2007)
Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system. Arch. Physiol. Biochem., 113: 186-201.
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7) Cansev M, Yilmaz MS, Ilcol YO, Hamurtekin E, Ulus IH (2007)
Cardiovascular effects of CDP-choline and its metabolites: involvement of peripheral autonomic nervous system. Eur. J. Pharmacol., 577: 129-142.
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8) Sakamoto T, Cansev M, Wurtman RJ (2007)
Oral supplementation with docosahexaenoic acid and uridine-5’-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res., 1182: 50-59.
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9) Ilcol YO, Cansev M, Yilmaz MS, Hamurtekin E, Ulus IH (2008)
Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: peripheral muscarinic and nicotinic acetylcholine receptors are both involved in its action. Neurosci. Lett., 431: 71-76.
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10) Cansev M, Ilcol YO, Yilmaz MS, Hamurtekin E, Ulus IH (2008)
Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations. Auton. Autacoid Pharmacol., 28: 41-58. doi: 10.1111/j.1474-8673.2007.00416.x.
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11) Isbil-Buyukcoskun N, Ilcol YO, Cansev M, Ozluk K, Hamurtekin E, Ulus IH (2008)
Central choline suppresses plasma renin response to graded hemorrhage in rats. Clin. Exp. Pharmacol. Physiol., 35: 1023-1031. doi: 10.1111/j.1440-1681.2008.04978.x.
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12) Cansev M, Ilcol YO, Yilmaz MS, Hamurtekin E, Ulus IH (2008)
Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system. Eur. J. Pharmacol., 589: 315-322. doi: 10.1016/j.ejphar.2008.05.017.
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13) Cansev M, Ulus IH, Wang L, Maher TJ, Wurtman RJ (2008)
Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson’s disease. Neurosci. Res., 62: 206-209. doi: 10.1016/j.neures.2008.07.005.
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14) Cansev M, Marzloff G, Sakamoto T, Ulus IH, Wurtman RJ (2009)
Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups. Dev. Neurosci., 31: 181-192. doi: 10.1159/000193394.
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15) Ilcol YO, Yilmaz Z, Cansev M, Ulus IH (2009)
Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: involvement of the peripheral nicotinic acetylcholine receptors. Shock, 32: 286-294. doi: 10.1097/SHK.0b013e3181971b02.
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16) Yilmaz Z, Ozarda Y, Cansev M, Eralp O, Kocaturk M, Ulus IH (2010)
Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia. Blood Coagul. Fibrinolysis, 21: 339-348. doi: 10.1097/MBC.0b013e328338ce31.
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17) Akkoc A, Kahraman MM, Cansev M, Ozyigit MO (2011)
Effects of hypoxia and hyperosmosis on the expression of matrix metalloproteinases in broiler lung fibroblasts. Avian Biol. Res. 4: 6-16. doi: 10.3184/175815511X13000117548916.
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18) Tvarijonaviciute A, Kocaturk M, Cansev M, Tecles F, Ceron JJ, Yilmaz Z (2012)
Serum butyrylcholinesterase and paraoxonase 1 in a canine model of endotoxemia: Effects of choline administration. Res Vet Sci. 93: 668-674. doi: 10.1016/j.rvsc.2011.09.010.
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19) Caner B, Kafa IM, Bekar A, Kurt A, Cansev M, Ulus IH (2012)
Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury. Neurol Res. 34: 238-245. doi: 10.1179/1743132812Y.0000000003.
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20) Savran M, Bekar A, Cansev M, Tolunay S, Ulus IH, Taskapilioglu MO (2012)
Prevention of epidural fibrosis in rats by local or systemic administration of citicoline. Turk Neurosurg. 22: 634-640. doi: 10.5137/1019-5149.JTN.6008-12.0.
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21) Cansev M, Minbay Z, Goren B, Yaylagul EO, Cetinkaya M, Koksal N, Alkan T (2013)
Neuroprotective effects of uridine in a rat model of neonatal hypoxic-ischemic encephalopathy. Neurosci. Lett., 542: 65-70. doi: 10.1016/j.neulet.2013.02.035.
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22) Cetinkaya M, Cansev M, Cekmez F, Tayman C, Canpolat FE, Kafa IM, Uysal S, Tunc T, Sarici SU (2013)
CDP-choline reduces severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis. J Surg Res. 183(1):119-128. doi: 10.1016/j.jss.2012.11.032.
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23) Cetinkaya M, Cansev M, Kafa IM, Tayman C, Cekmez F, Emre Canpolat F, Tunc T, Sarici SU (2013)
Cytidine 5'-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model. Pediatr. Res. 74(1):26-33. doi: 10.1038/pr.2013.68.
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24) Kaplan T, Kafa IM, Cansev M, Bekar A, Karli N, Taskapilioglu MO, Kanar F (2014)
Investigation of the Dose-Dependency of Citicoline Effects on Nerve Regeneration and Functional Recovery in a Rat Model of Sciatic Nerve Injury. Turkish Neurosurgery, 24: 54-62. doi: 10.5137/1019-5149.JTN.8451-13.0.
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25) Ozarda Y, Cansev M, Ulus IH (2014)
Relations of Human Breastmilk Choline Content with Maternal Hormonal Status. Breastfeed Med, 9: 39-41. doi: 10.1089/bfm.2013.0029.
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26) Ozarda Y, Cansev M, Ulus IH (2014)
Breast Milk Choline Contents Are Associated with Inflammatory Status of Breastfeeding Women. J Hum Lact. 30(2): 161-166. doi: 10.1177/0890334413508004.
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27) Cetinkaya M, Erener-Ercan T, Cansev M, Buyukkale G, Cekmez F, Aydemir G, Pirhan D, Genc FA, Acar E, Taskin N (2014)
The utility of serial plasma sE-selectin measurements in the prediction of retinopathy of prematurity in premature infants. Early Hum Dev. 90: 517-521. doi: 10.1016/j.earlhumdev.2014.03.009.
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28) Cansev M, van Wijk N, Turkyilmaz M, Orhan F, Sijben JW, Broersen LM (2015)
A specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats. Neurobiol. Aging, 36: 344-351. doi: 10.1016/j.neurobiolaging.2014.07.021.
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29) Cansev M, Orhan F, Yaylagul EO, Isik E, Turkyilmaz M, Aydin S, Gumus A, Sevinc C, Coskun N, Ulus IH, Wurtman RJ (2015)
Evidence for the existence of pyrimidinergic transmission in rat brain. Neuropharmacology, 91: 77-86. doi: 10.1016/j.neuropharm.2014.12.019.
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30) Cetinkaya M, Cansev M, Cekmez F, Tayman C, Emre Canpolat F, Kafa IM, Yaylagul EO, Kramer BW, Sarici SU (2015)
Protective effects of valproic acid, a histone deacetylase inhibitor, against hyperoxic lung injury in a neonatal rat model. PLoS One, 10(5):e0126028. doi: 10.1371/journal.pone.0126028.
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31) Yaylagul EO, Cansev M, Celikler S (2015)
In vivo protective effect of Uridine, a pyrimidine nucleoside, on genotoxicity induced by Levodopa/Carbidopa in mice. Food Chem Toxicol, 82: 36-41. doi: 10.1016/j.fct.2015.05.002.
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32) Koyuncuoglu T, Turkyilmaz M, Goren B, Cetinkaya M, Cansev M, Alkan T (2015)
Uridine protects against hypoxic-ischemic brain injury by reducing histone deacetylase activity in neonatal rats. Restor Neurol Neurosci, 33: 777-784. doi: 10.3233/RNN-150549.
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33) Gundogdu EB, Bekar A, Turkyilmaz M, Gumus A, Kafa IM, Cansev M (2016)
CDP-choline modulates matrix metalloproteinases in rat sciatic injury. J Surg Res, 200: 655-663. doi: 10.1016/j.jss.2015.10.003.
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34) van Wijk N, Balvers M, Cansev M, Maher TJ, Sijben JW, Broersen LM (2016)
Dietary Crude Lecithin Increases Systemic Availability of Dietary Docosahexaenoic Acid with Combined Intake in Rats. Lipids, 51(7): 833-846. doi: 10.1007/s11745-016-4139-8.
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35) Yilmaz Z, Eralp Inan O, Kocaturk M, Baykal AT, Hacariz O, Hatipoglu I, Tvarijonaviciute A, Cansev M, Ceron J, Ulus IH (2016)
Changes in serum proteins after endotoxin administration in healthy and choline-treated calves. BMC Vet Res, 12: 210. doi: 10.1186/s12917-016-0837-y.
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36) Kocaturk M, Eralp-Inan O, Tvarijonaviciute A, Cansev M, Ozyigit MO, Ceron JJ, Yilmaz Z, Kahraman MM (2016)
Effects of choline treatment in concentrations of serum matrix metalloproteinases (MMPs), MMP tissue inhibitors (TIMPs) and immunoglobulins in an experimental model of canine sepsis. Vet Immunology Immunopathol, 180: 9-14. doi: 10.1016/j.vetimm.2016.08.011.
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37) Sever M, Turkyilmaz M, Sevinc C, Cakir A, Ocalan B, Cansev M, Guler MO, Tekinay AB (2016)
Regenerative effects of peptide nanofibers in an experimental model of Parkinson's disease. Acta Biomater, 46: 79-90. doi: 10.1016/j.actbio.2016.09.011.
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38) Goren B, Cakir A, Ocalan B, Serter Kocoglu S, Alkan T, Cansev M, Kahveci N (2017)
Long-term cognitive effects of uridine treatment in a neonatal rat model of hypoxic-ischemic encephalopathy. Brain Res, 1659: 81-87. doi: 10.1016/j.brainres.2017.01.026.
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39) Cansev M, Turkyilmaz M, Sijben JWC, Sevinc C, Broersen LM, van Wijk N (2017)
Synaptic Membrane Synthesis in Rats Depends on Dietary Sufficiency of Vitamin C, Vitamin E, and Selenium: Relevance for Alzheimer's Disease. J Alzheimers Dis. 59(1):301-311. doi: 10.3233/JAD-170081.
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40) Goren B, Cakir A, Sevinc C, Serter Kocoglu S, Ocalan B, Oy C, Minbay Z, Kahveci N, Alkan T, Cansev M (2017)
Uridine treatment protects against neonatal brain damage and long-term cognitive deficits caused by hyperoxia. Brain Res. 1676:57-68. doi: 10.1016/j.brainres.2017.09.010.
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41) Gurel B, Cansev M, Sevinc C, Kelestemur S, Ocalan B, Cakir A, Aydin S, Kahveci N, Ozansoy M, Taskapilioglu O, Ulus IH, Başar MK, Sahin B, Tuzuner MB, Baykal AT (2018)
Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer's Disease Mouse Model. J Alzheimers Dis. 61(4):1399-1410. doi: 10.3233/JAD-170329.
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